David C Knoppert, MScPhm, FCCP, MSc


Children’s Health Research Institute

Scientist, Children’s Optimal Therapeutics Program


Lawson Health Research Institute
Associate Scientist, Children’s Health Research Institute


University of Western Ontario
Assistant Professor, Department of Medicine

Adjunct Professor, Department of Paediatrics


Other Appointments
Liaison Pharmacist, NICU, St. Joseph’s Health Care London

Clinical Coordinator, NICU, St. Joseph's Health Care London

Contact Information
Tel: (519) 685-8500 Ext. 65532
Fax: (519) 646-6003
E-mail: dave.knoppert@sjhc.london.on.ca


Brief Biography

Mr. David Knoppert received his Bachelor of Pharmacy degree from the University of Toronto in 1980. He then completed a Residency in Hospital Pharmacy at University Hospital in London and began as a staff pharmacist at The Hospital for Sick Children in Toronto. In 1986, he completed an MScPhm from the University of Toronto where he worked in Clinical Pharmacology with Drs. Michael Spino and Stuart McLeod. In 1986, he became the NICU Pharmacist at St. Joseph’s Hospital in London. In 2004, he completed his MSc-Clinical Epidemiology from The University of Western Ontario.


Research Interests

Mr. Knoppert’s research interests are in the areas of neonatal therapeutics (pharmacokinetics, pharmacodynamics), the effects of drugs in pregnancy on the newborn and drugs and breastfeeding.


Research Activities

Current research projects include subcutaneous administration of Vitamin A in premature newborns, the prophylactic use of metoclopramide in premature newborns and a dose response study of domperidone use to enhance breast milk production. Future research projects include retrospective studies on the use of enoxaparin and indomethacin in the premature newborn, in addition to the effects of SSRI exposure on the newborn.

 

Awards and Recognition

 

Fellow - Awarded by Canadian Society of Hospital Pharmacy

 

Jack Burghardt Award of Excellence - Awarded by The Salvation Army

 

Glen S Wither Award for Research - Awarded by Schulich School of Medicine, University of Western Ontario

 

Funding in support of "Correlation of clinical symptoms with serum levels and CYP2D6 status in newborns who were exposed to paroxetine in utero". - Awarded by Children's Hospital of Western Ontario


Publications

  1. Janet I Malowany, Paul Monagle, David C Knoppert, David SC Lee, John Wu, Patricia McClusker, M Patricia Massicotte, Suzan Williams, Anthony KC Chan. Enoxaparin for neonatal thrombosis : a call for a higher dose for neonates. Thrombosis Research 2008;122:825-30
  2. Knoppert D, Arenas-Lopez S, McArtney R : The infancy of an international paediatric pharmacy network. European Journal of Hospital Pharmacy Practice 2008;13:28-30
  3. Cherry A, Knoppert D, Lee D, Pletsch D, Seabrook J : Utilization of opioid infusions in the Neonatal Intensive Care Unit (NICU). J Pediatr Pharmacol Ther 2007;12 (4): 251-2.
  4. Matsui D, Knoppert D.  Drugs and Chemicals Most Commonly Used by Pregnant Women.  In:  Koren G, ed.  Medication Safety in Pregnancy and Breastfeeding.  New York:  McGraw-Hill Companies, Inc.  2007;75-83
  5. Malowany JI, Knoppert DC, Lee DSC, Wu J, McCusker P, Massicotte P, Williams S, Chan AKC. Differential dosing of enoxaparin (ENOX) in term and preterm neonates, XXIst Congress of the International Society on Thrombosis and Haemostasis.  Geneva, Switzerland (July 6 - 12, 2007)
  6. Malowany Janet, Knoppert David, Chan Anthony, Pepelassis Dion, Lee David. Enoxaparin use in the neonatal intensive care unit  (NICU) : experience over 8 years. Pharmacotherapy 2007;27:1263-1271.
  7. Knoppert D, Lee D. Ganciclovir overdose in a premature newborn (Abstract). J Pediatr Pharmacol Ther 2006;11:176.
  8. Knoppert D : You’re a What ? In a What ? The NICU Pharmacist. Advocate (A publication of the Ontario Society of Medical Technologists) 2006;13 ;14-15.
  9. Knoppert DC, Nimkar R, Principi T, Yuen D. Paroxetine toxicity in a newborn after in utero exposure. Therapeutic Drug Monitoring 2006:28:5-7.
  10. Matsui D and Knoppert DC (2005). SSRI Therapy During Pregnancy: Effects on the Newborn. Therapeutic Drug Monitoring 27:544-5.
  11. daSilva OP and Knoppert D (2004). Domperidone for lactating women. Canadian Medical Association Journal. 171(7):725-6.
  12. Knoppert DC, Sultan N, Bassoo E, Nimkar R (2003). Serotonin reuptake discontinuation syndrome in the newborn - a case report (Abstract No 55). The Canadian Journal of Clinical Pharmacology 10:140.
  13. Karen Antoni, David Knoppert, Michael Keim, Sheeva Woznuk, and Vivian Capewell (2003). Developing skills in critical appraisal. Canadian Nurse 99:24-26.
  14. Knoppert DC, Stempak D, Baruchel S, Koren G (2003). Celecoxib in human milk – a case report. Pharmacotherapy 23:97-100.
  15. da Silva OP, Kumaran VS, Knoppert DC (2002). Randomised controlled trial comparing two regimes of dexamethasone in the neonate with chronic lung disease. Pediatric Research 51(4):2146(A).