Asuri Narayan Prasad
Affiliations
Associate Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Associate Scientist, Lawson Health Research Institute
Paediatric Neurologist, Paediatric Neurology, Children’s Hospital, London Health Science Centre
Director, Paediatric Epilepsy Monitoring Service, Children’s Hospital, London Health Sciences Centre
How my research helps children
My research involves bridging the knowledge gap between the patient bedside and the lab bench. Perspectives gleaned from clinical observations are critical in the generation of new hypothesis and new directions into research. A major part of my work is directed towards better clinical understanding of rare genetic and metabolic disorders, so that treatment options can be widened.
Research
Current Research Activities
Specific areas of research interest are:
• Epidemiology and natural history of childhood epilepsy
• Organic acidemias, in particular glutaricaciduria; neurochemistry and neuropathological aspects, animal models
• Genetic and neurobiological basis of pervasive developmental disorders
• Genetic basis of epilepsy, metabolic basis of neurological disorders
• Epileptic encephalopathies of infancy and childhood
• Cerebral morphogenesis, developmental controls of brain and craniofacial structure with reference to agenesis of the corpus callosum, neuronal migration defects, and holoprosencephaly
As a research scientist (Associate Scientist at Lawson Health Research Institute and the Child Health Program,) and scholar, Dr. Prasad has made several unique contributions. He has been successfully awarded many grants and research awards. He has over 100 publications (original papers and published abstracts in peer reviewed journals). His papers have been cited in many leading journals in the field of neurosciences and epilepsy. He has presented his work at national and international conferences where he has been an invited speaker. He has served as a peer reviewer for many leading international journals (Epilepsia, Archives of Diseases of Childhood, Epilepsy Research, Developmental Medicine & Child Neurology) and as a member of the Scientific Committee of the American Epilepsy Society.
Research Team
Work in collaboration with Dr. Chitra Prasad, Dr. Victoria Siu, Dr. T Rupar, Dr. M Rieder in the Department of Pediatrics and Dr. N Rajakumar in the Department of Anatomy and Cell Biology
Future Research Plans
Continuing work along themes already established towards understanding of epilepsy and neurological disease in rare genetic and metabolic disorders
Awards & Grants
Awards & Grants
Funding in support of establishing an animal model of Glutaric aciduria Type-1 A common Pediatric Neurological Problem among the Aboriginal Population of Northwestern Ontario and Manitoba – Awarded by The University of Western Ontario, Lawson Health Research Institute and Children’s Health Research Institute
Recent Publications
Publications
Early onset epilepsy and inherited metabolic disorders: diagnosis and management Prasad AN, Hoffmann GF Can J Neurol Sci. 2010 May;37(3):350-8.
Relationship between antiepileptic drugs and biological markers affecting long-term cardiovascular function in children and adolescents Cheng LS, Prasad AN, Rieder MJ. Can J Clin Pharmacol. 2010 Winter;17(1):e5-46
Status epilepticus in the pediatric ICU: state of the art Prasad AN Can J Neurol Sci. 2009 Aug;36 Suppl 2:S92-8
Primary disorders of metabolism and disturbed fetal brain development Prasad AN, Malinger G, Lerman-Sagie T. Clin Perinatol. 2009 Sep;36(3):621-38.
Susceptibility to febrile seizures: more than just a faulty thermostat! Prasad AN, Seshia SS. Can J Neurol Sci. 2009 Jul;36(4):A-23
Live/real time three-dimensional transthoracic echocardiographic assessment of pulmonary regurgitation Pothineni KR, Wells BJ, Hsiung MC, Nanda NC, Yelamanchili P, Suwanjutah T, Prasad AN, Hansalia S, Lin CC, Yin WH, Young MS. Echocardiography. 2008 Sep;25(8):911-7.
Assessment of systolic and diastolic left ventricular and left atrial function using vector velocity imaging in Takotsubo cardiomyopathy Burri MV, Nanda NC, Lloyd SG, Hsiung MC, Dod HS, Beto RJ, Bhardwaj R, Jain A, Jackson J, Agarwal A, Chaurasia P, Prasad AN, Manda J, Pothineni KR. Echocardiography. 2008 Nov;25(10):1138-44.
Exophytic choroid plexus papilloma of the fourth ventricle presenting with cerebrospinal fluid rhinorrhea: a case report Symss NP, Prasad AN, Vasudevan MC, Ramamurthi R. Surg Neurol. 2009 Jun;71(6):705-8
Unilateral palatal palsy with viral hepatitis Prasad PL, Prasad AN, Patnaik SK. Indian J Pediatr. 2007 Nov;74(11):1039-40
Agenesis of the corpus callosum and cerebral anomalies in inborn errors of metabolism Prasad AN, Bunzeluk K, Prasad C, Chodirker BN, Magnus KG, Greenberg CR. Congenit Anom (Kyoto). 2007 Dec;47(4):125-35
Contact
Contact
Phone: 519-685-8500 x 57455
Fax: 519-685-8350
Email: narayan [dot] prasad [at] lhsc [dot] on [dot] ca