Dave Freeman
Affiliations
Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Associate Professor, Departments of Medicine (Clinical Pharmacology), Physiology & Pharmacology, Paediatrics, Schulich School of Medicine & Dentistry, Western University
How my research helps children
Our work involves collaborative studies with paediatricians and other clinicians to solve therapeutic issues related to drug use in children. Activities include phenotyping of metabolic enzymes and measurement of drug concentrations in plasma and other biological fluids for the purpose of therapeutic drug monitoring.
Research
Current Research Activities
Our research covers several areas and is based on team-work between clinical and basic scientists. Current work centers on strategies for lowering total plasma homocysteine, an independent risk factor for stroke and atherosclerosis, in patients with end-stage renal disease. These are collaborative studies with nephrologists and cardiovascular specialists.Other projects include the study of methadone concentrations in neonates, and the analysis of polyphenolic compounds in natural products and complementary medicines.
Research Team
The laboratory team is made up of one graduate student and a technologist. We also train and supervise graduate students from other labs who require our expertise in analytical HPLC and pharmacokinetics.
Future Research Plans
The laboratory will continue work on drug assay development for the purpose of pharmacokinetic analysis related to drug and xenobiotic issues in patient populations.
Awards & Grants
Awards & Grants
Funding in support of PoP Program: Homocysteine-lowering Strategies in Haemodialysis Patients – Awarded by Canadian Institute of Health Research (CIHR)
Funding in support of Genotype-specific Approaches to Therapy in Childhood (GATC) – Awarded by Genome Canada
Funding in support of Baseline Biomonitoring Studies and a Survey of Child-Youth Health as Prerequisites to Epidemiological Studies to Assess the Health Risk of the Attawapiskat First Nation and Walpole Island First Nation Communities from Exposure to Environmental Contaminants – Awarded by Assembly of First Nations Health Canada National First Nations
Recent Publications
Publications
Thiol exchange: an in vitro assay that predicts the efficacy of novel homocysteine lowering therapies Urquhart BL, House AA, Cutler MJ, Spence JD, Freeman DJ. J Pharm Sci. 2006 Aug;95(8):1742-50.
Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference Zheng X, Koropatnick J, Li M, Zhang X, Ling F, Ren X, Hao X, Sun H, Vladau C, Franek JA, Feng B, Urquhart BL, Zhong R, Freeman DJ, Garcia B, Min WP. J Immunol. 2006 Oct 15;177(8):5639-46
In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract Ferguson PJ, Kurowska EM, Freeman DJ, Chambers AF, Koropatnick J Nutr Cancer. 2006;56(1):86-94.
The Effect of Mesna on Plasma Total Homocysteine Concentrations in Hemodialysis Patients. Urquhart BL, Freeman DJ, Spence JD, House AA. Am J Kidney Dis. 2006; 49 (1): 109-17.
Mesna as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis. Urquhart BL, Freeman DJ, Spence JD, House AA. J Clin Pharmacol. 2007; 47(8): 991-7.
Mesna for the treatment of hyperhomocysteinemia in hemodialysis patients: a placebo controlled double-blind randomized trial. Urquhart B, Freeman DJ, Cutler MJ, Mainra R, Spence JD, House AA. Clin J Am Soc Nephrol. 2008 Mar 12.
Timolol concentrations in breast milk of a woman treated for glaucoma: Calculation of neonatal exposure. Parvaz Madadi BMSc , Gideon Koren MD , David J. Freeman PhD, Reinhard Oertel PhD, Robert J. Campbell MD, MSc, Graham E. Trope MB, PhD. J Glaucoma 2008; 17(4): 329-31
Mesna for the Treatment of Hyper- homocysteinemia in Hemodialysis Patients. Murray J. Cutler, BMSc (Hons), Bradley L. Urquhart, PhD, David J. Freeman, PhD, J. David Spence, MD, Andrew A. House, MD. Blood Purification 2009; 27(3): 306-310.
Compensatory upregulation of the adenosine system following phenylephrine-induced hypertrophy in cultured rat ventricular myocytes Pang T, Gan XT, Freeman DJ, Cook MA, Karmazyn M. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H545-53
Contact
Contact
Phone: 519-685-8500 x 34224
Fax: 519-663-3232
Email: dfreeman [at] uwo [dot] ca