David Knoppert
Affiliations
Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Clinical Pharmacy Coordinator, Pharmacy, St. Joseph’s Health Care, London
Adjunct Professor, Departments of Paediatrics/Paediatric Clinical Pharmacology, Clinical Pharmacology/Medicine and Neonatology, Schulich School of Medicine & Dentistry, Western University
How my research helps children
My research helps us understand the effects of drugs taken during pregnancy on the newborn baby and whether or not there are long-term effects of this exposure. My research on the effects of drugs and how they are metabolized allows us to better prescribe drugs for premature babies.
Research
Current Research Activities
The short term effects of methadone exposure during pregnancy on the newborn baby.
The use of domeperidone to increase breast milk supply in new mothers.
Research Team
Dr. Laura Lyons – Obstetrician who can prescribe methadone
Dr. Doreen Matsui – Pediatric Clinical Pharmacologist
Dr. David Lee - Neonatologist
Dr. Henry Roukema - Neonatologist
Dr. Orlando daSilva - Neonatologist
Dr. Ute Schwarz – Clinical Pharmacologist
Dr. David Freeman - Pharmacologist
Mr. Jamie Seabrook - Statistician
Ms. Joanne Warren – Lactation Consultant
Ms. Michelle Angelini - Lactation Consultant
Ms. Michelle Carr - Lactation Consultant
Past trainees
Dr. Andrea Page – medical student who worked on domperidone study; presently a physician
Ms. Amanda Suarez – pharmacy resident who worked on methadone study; presently a hospital pharmacist
Ms. Shalene Wong - – pharmacy resident who worked on methadone study; presently a hospital pharmacist
Future Research Plans
1. To examine the long term effects, if any, of in utero methadone exposure.
2. To further characterize the metabolism of methadone during pregnancy and in the newborn.
3. To look at the effects and pharmacokinetics of oral and IV ibuprofen in premature newborn babies.
Awards & Grants
Awards & Grants
Funding in support of "Enhancing Breast Milk Production with Domperidone in Mothers of Preterm Neonates (EMPOWER Trial)– Awarded by Canadian Institute for Health Research (CIHR)
Jack Burghardt Award of Excellence – Awarded by The Salvation Army
Malowany J : Glen S Wither Award for Research – Awarded by The University of Western Ontario
Funding in support of The pharmacokinetics and acute effects of in utero methadone exposure in newborns – Awarded by Children’s Health Foundation
Funding in support of Correlation of clinical symptoms with serum levels and CYP2D6 status in newborns who were exposed to paroxetine in utero – Awarded by The Children’s Health Research Institute (CHRI)
Fellowship – Awarded by Canadian Society for Hospital Pharmacy
Recent Publications
Publications
The Worldwide Opioid Epidemic - Implications for Treatment and Research in Pregnancy and the Newborn. Knoppert DC. Pediatric Drugs. 2011;13(5):277-9.
Opioid Infusions in the Neonatal Intensive Care Unit. Suarez A, Knoppert DC, Lee DSC, Pletsch D, Seabrook JA. J Pediatr Ther. 2010;15(2):142-6.
Pediatric formulations: international issues and potential solutions Knoppert DC Paediatr Drugs. 2009;11(1):55-6.
Enoxaparin for neonatal thrombosis: a call for a higher dose for neonates Malowany JI, Monagle P, Knoppert DC, Lee DS, Wu J, McCusker P, Massicotte MP, Williams S, Chan AK, Canadian Paediatric Thrombosis And Hemostasis Network Thromb Res. 2008;122(6):826-30.
Enoxaparin use in the neonatal intensive care unit: experience over 8 years Malowany JI, Knoppert DC, Chan AK, Pepelassis D, Lee DS Pharmacotherapy. 2007 Sep;27(9):1263-71
Paroxetine toxicity in a newborn after in utero exposure: clinical symptoms correlate with serum levels Knoppert DC, Nimkar R, Principi T, Yuen D. Ther Drug Monit. 2006 Feb;28(1):5-7
Contact
Phone: 519-685-8500 x 65532
Fax: 519-685-8536
Email: dave [dot] knoppert [at] lhsc [dot] on [dot] ca