Elizabeth P. Hayden
Affiliations
Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Associate Professor, Department of Psychology, Western University
How my research helps children
In my lab, we are interested in examining linkages between genes, temperament, cognition, and mood disorders within a developmental psychopathology framework. Our research on this issue includes children and adults, as well as clinical and non-clinical samples, with an emphasis on longitudinal designs and multimethod assessment strategies. We strive to take a “top-down” approach to depression vulnerability, incorporating both biological and contextual variables in our projects, and to use developmentally sensitive measures of behavior. Current projects include a SSHRC-funded study of the associations between child emotional behavior and cognitive vulnerability to depression and anxiety, and a study of gene-environment interactions and cortisol reactivity in predicting childhood emotional development (funded by Canadian Institute of Health Research). The long-term goal of my work is to better identify early-emerging predictors of risk for depression to help inform early prevention and intervention.
Research
Current Research Activities
In my lab, we are interested in examining linkages between genes, temperament, cognition, and mood disorders within a developmental psychopathology framework. Our research on this issue includes children and adults, as well as clinical and non-clinical samples, with an emphasis on longitudinal designs and multimethod assessment strategies. We strive to take a “top-down” approach to depression vulnerability, incorporating both biological and contextual variables in our projects, and to use developmentally sensitive measures of behavior. Current projects include a SSHRC-funded study of the associations between child emotional behavior and cognitive vulnerability to depression and anxiety, and a study of gene-environment interactions and cortisol reactivity in predicting childhood emotional development (funded by Canadian Institute of Health Research)
Research Team
Katie Kryski is a second year Ph.D. student in Clinical Psychology. Her research interests include exploring the development of mood disorders in childhood with a gene-environment interactionist perspective and the ability of psychophysiological reactivity and recovery to inform these interactions
Heather Smith is a first year Ph.D. student in Clinical Psychology. Her research involves the study of effortful control and emotion regulation and the interplay of these constructs with biological vulnerability to determine later adjustment.
Sarah Mackrell is a first year Ph.D. student in Personality and Measurement. Her research involves the study of temperament and developmental differences in physiological reactivity and recovery.
Haroon Sheikh's (a second-year Ph.D. student in Biology) current project is to investigate if the val66met polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) is modulating HPA-axis reactivity in pre-school aged children. His long-term goals include mapping genomic variants that might be involved in cognitive vulnerability during early-development.
Awards & Grants
Awards & Grants
Funding in support of "A preliminary investigation of the structural neural correlates of early stress – Awarded by Academic Development Fund (ADF)
Funding in support of “Temperamental Emotionality in Preschoolers and Depression Risk” – Awarded by National Institute of Mental Health, US
Funding in support of “Emerging childhood vulnerability to depression: Biological, emotional, and cognitive pathways” – Awarded by Ontario Ministry of Research and Innovation
Funding in support of “Gene-environment interplay and the developmental psychopathology of internalizing disorders” – Awarded by Canadian Institute of Health Research (CIHR)
Funding in support of “Childhood temperamental vulnerability to internalizing psychopathology: Emotional and cognitive pathways” – Awarded by Social Sciences and Humanities Research Council
Funding in support of “Cognitive vulnerability in adolescents at risk for depression” – Awarded by Ontario Mental Health Foundation
Funding in support of “Molecular genetics of child temperament” – Awarded by National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD), USA
Recent Publications
Publications
Assessing stress reactivity indexed via salivary cortisol in preschool-aged children. Kryski KR, Smith HJ, Sheikh HI, Singh SM, Hayden EP. Psychoneuroendocrinology. 2011; 36, 1127-1136
Maternal personality influences the relationship between maternal reports and laboratory measures of child temperanent. Hayden EP, Durbin CE, Klein DN, Olino TM. J Personality Assessment. 2010; 92, 586-593
The role of BDNF genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality. Hayden EP, Klein DN, Dougherty LR, Olino TM, Dyson MW, Durbin CE, Sheikh HI, Singh SM. Psychological Science. 2010; 21, 1678-1685
The Dopamine D2 Receptor Gene and depressive and anxious symptoms in childhood: Associations and evidence for gene-environment correlation and gene-environment interaction. Hayden EP, Klein DN, Dougherty LR, Olino TM, Durbin CE, Sheikh HI, Singh SM. Psychiatric Genetics. 2010; 20, 304-310
The serotonin transporter promoter polymorphism and childhood positive and negative emotionality. Hayden EP, Klein DN, Olino TM, Dougherty LR, Durbin CE, Sheikh HI, Singh SM. Emotion. 2010; 10, 696-702
Genotyping the BDNF rs6265 (val66met) polymorphism by one-step Amplified Refractory Mutation System PCR. Sheikh, H.I., Hayden, E.P., Kryski, K.R., Smith, H.J., & Singh, S. Psychiatr Genet. 2010 Jun;20(3):109-12
Interaction Between 5-HTTLPR and BDNF Val66Met Polymorphisms on HPA Axis Reactivity in Preschoolers Dougherty, L.R., Klein, D.N., Congdon, E., Canli, T., & Hayden, E.P. Biol Psychol. 2010 Feb;83(2):93-100
Glucagon-Like Peptide-1 Receptor Gene polymorphism (Leu260Phe) is associated with morning cortisol in preschoolers Sheikh, H.I., Dougherty, L.R., Hayden, E.P., Klein, D.N., & Singh, S Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 15
Temperamental positive and negative emotionality and children's depressive symptoms: A longitudinal prospective study from age three to age ten Dougherty, L. R., Klein, D. N., Durbin, C. E., Hayden, E. P., & Olino, T. M. Journal of Social and Clinical Psychology, 29, 464-490. (2010)
Contact
Contact
Phone: 519.661.3686
Fax: 519.850.2554
Email: ehayden [at] uwo [dot] ca
Website: http://www.ssc.uwo.ca/psychology/faculty/hayden_res.htm
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