Gideon Koren
Affiliations
Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Professor, Departments of Medicine, Paediatrics, Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University
Ivey Chair in Molecular Toxicology, Western University
Director, The Motherisk Program, The Toronto Hospital for Sick Children
Professor, Departments of Paediatrics, Pharmacology, Pharmacy and Medical Genetics, University of Toronto
How my research helps children
My work helps identify pharmacological and toxicological determinants of maternal, fetal and child health, both in terms of medicinal drugs, as well as environmental toxins.
Research
Current Research
Currently, Dr. Koren’s research at Western University includes a wide range of topics in the field of clinical pharmacology. He has ongoing projects looking at drugs in pregnancy and breastfeeding, adverse drug reactions and events, environmental toxicology and applications for hair cortisol as a biomarker for stress.
Research Team
Since his start as the Ivey Chair in Molecular Toxicology at Western University, Dr. Koren has trained ten graduate students who have successfully defended their theses. At present, his lab consists of six graduate students in both the MSc and PhD programs. Following the defense of two of his current masters students, several more trainees will become a part of Dr. Koren’s team this fall (2010). Dr. Koren has collaborations with Dr. Stan Van Uum, Dr. Jack Bend and Dr. Michael Rieder.
Awards & Grants
Awards & Grants
Access to data from the Norwegian Mother and Child Cohort - The University of Oslo and the Foundation for the Promotion of Norwegian Pharmacies (H. Nordeng-PI) (co-I).
Medication use in pregnance with focus on attitudes, perception of risk and mental well-being - The University of Oslo (H. Nordeng-PI) (co-I).
Long term neurodevelopmental outcome after exposure to psychotropic drugs during pregnance - The Norwegian Research Council (H. Nordeng-PI) (co-I).
International Registry for Gilenya in Multiple Sclerosis - Novartis Inc. (G. Koren-PI).
Developing GeneMed for Canada, Pilot Study - University of Toronto Centre for Applied Genomics (G. Koren-PI).
GeneMed in children - Ontario Ministry of Health (S. Ito-PI) (co-I).
CHIP-Child- Testing the Fetal Programming Hypothesis - CIHR (L. Magee-PI) (co-I).
Development of clinical practice guideline for pharmacogenetic testing - CIHR (B. Carleton-PI) (co-I).
Doctoral Research Award - Priority Announcement - Childhood Cancer (SHOPP), CIHR-Partnerships and Citizen Engineering/CIHR - Institute of Cancer Research/Paediatric Oncology Group of Ontario. (Lauren Hanly - PhD Candidate).
NIH - Pain in preterm infants in development and effects. (R. Grunan-PI) (Co-applicant).
The Ivey Chair in Molecular Toxicology, University of Western Ontario (PI).
CIHR - Canadian Pharmacogenetic Network for Drug Safety: (B Carleton, M Hayden, PIs) (co-investigator, site PI).
Walkerton Clean Water Center: Bisphenol A and children’s health(with Dr. Yanful). (co-PI)
CIHR - Renal handling of drugs during development (PI)
First Nation & Inuit Branch - Baseline biomonitoring studies and a survey of child-youth health as prerequisites to epidemiological studies to assess the health risk of the Attawapiskat first nation and Walpole island first nation. (J. Bend, PI) (Co-applicant).
North Carolina Translational and Clinical Science Institute. Hair cortisol as a biomarker of chronic HPA axis response to stress. (A. Sanders, PI) (Co-applicant)
American Association of Critical Nurses. The Vulnerable Infant Population (VIP) perinatal stress study. (Purdy I, UCLA, PI). (Co-applicant).
Recent Publications
Publications
Aleksa K, Liesivuouri J, Koren G. Hair as a biomarker of polybrominated ditheyl ethers' exposure in infants, children and adults. Toxicol Lett. 2011. [Epub ahead of print]
Gedeon C, Nava-Ocampo AA, Koren G. Ethical issues in pharmacologic research in women undergoing pregnancy termination: a systematic review and survey of researchers. Obstet Gynecol Int. 2012; 2012:724591.
Aleksa K, Walasek P, Fulga N, Kapur B, Gareri J, Koren G. Simultaneous detection of seventeen drugs of abuse and metabolites in hair using solid phase micro extraction (SPME) with GC/MS. Forensic Sci Int. 2011. [Epub ahead of print]
Matok I, Levy A, Wiznitzer A, Uziel E, Koren G, Gorodischer R. The safety of fetal exposure to proton-pump inhibitors during pregnancy. Dig Dis Sci. 2012;699-705.
Vandervaart S, Berger H, Tam C, Goh YI, Gijsen VM, de Wildt SN, Taddio A, Koren G. The effect of distant reiki on pain in women after elective Caesarean section: a double-blinded randomised controlled trial. BMJ. 2011;e000021.
Gunness P, Aleksa K, Bend J, Koren G. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011;290-301.
Russell E, Koren G, Rieder M, Van Uum S. Hair cortisol as a biological marker of chronic stress: Current status, future directions, and unanswered questions. Psychoneuroendocrinology. 2012:589-601.
Gijsen V, Mital S, van Schaik RH, Soldin OP, Soldin SJ, van der Heiden I, Nulman I, Koren G, de Wildt SN. Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. J Heart Lung Transplant. 2011;1352-9.
Nurmohamed L, Moretti ME, Schechter T, Einarson A, Johnson D, Lavigne SV, Erebara A, Koren G, Finkelstein Y. Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic. Am J Obstet Gynecol. 2011;533.e1-3.
Hutson JR, Lubetsky A, Walfisch A, Ballios BG, Garcia-Bournissen F, Koren G. The transfer of 6-mercaptopurine in the dually perfused human placenta. Reprod Toxicol. 2011:349-53.
Lam J, Kelly L, Ciszkowski C, Landsmeer ML, Nauta M, Carleton BC, Hayden MR, Madadi P, Koren G. Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia. J Pediatr. 2012;33-7.
Contact
Phone: 519-661-2111 x 83128
Fax: 519-850-2932
Email: gkoren [at] uwo [dot] ca
Web: http://www.schulich.uwo.ca/moleculartoxicology
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