Scientist, Division of Children’s Health and Therapeutics, Children’s Health Research Institute
Professor, Departments of Medicine, Paediatrics, Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University
Ivey Chair in Molecular Toxicology, Western University
Director, The Motherisk Program, The Toronto Hospital for Sick Children
Professor, Departments of Paediatrics, Pharmacology, Pharmacy and Medical Genetics, University of Toronto
How my research helps children
My work helps identify pharmacological and toxicological determinants of maternal, fetal and child health, both in terms of medicinal drugs, as well as environmental toxins.
Currently, Dr. Koren’s research at Western University includes a wide range of topics in the field of clinical pharmacology. He has ongoing projects looking at drugs in pregnancy and breastfeeding, adverse drug reactions and events, environmental toxicology and applications for hair cortisol as a biomarker for stress.
Since his start as the Ivey Chair in Molecular Toxicology at Western University, Dr. Koren has trained ten graduate students who have successfully defended their theses. At present, his lab consists of six graduate students in both the MSc and PhD programs. Following the defense of two of his current masters students, several more trainees will become a part of Dr. Koren’s team this fall (2010). Dr. Koren has collaborations with Dr. Stan Van Uum, Dr. Jack Bend and Dr. Michael Rieder.
Awards & Grants
Awards & Grants
Post tonsillectomy use of opioids in children with obstructive sleep apnea - CIHR DSEN (G. Koren-PI).
Behavioral phenotype for FAS - Canadian Foundation for Fetal Alcohol Research (C. Rasmussen-PI).
Hair cortisol for stress in mothers of children with FASD - Canadian Foundation for Fetal Alcohol Research (S. VanUum-PI)
Pregnancy outcome following gestational exposure to Muscle Care products - Ontario Centers of Excellence (G. Koren-PI)
Using a mobile community research laboratory to improve understanding, treatment and prevention of addiction and mental illness co-morbidities at the individual and community level: The Ontario Communities Project (Emerging Team Grant) - CIHR NET grant (G. Koren-Co-I)
Surveillance program for diclectin in pregnancy - Duchesnay Inc. (G. Koren-PI)
Pharmacogenetics of adverse drug events - CIHR DSEN (M. Hayden-PI) (co-I)
Active Surveillance and evaluation of adverse reactions in Canadian healthcare (DSEN SEARCH) - CIHR DSEN (B. Carleton-PI) (co-I)
Access to data from the Norwegian Mother and Child Cohort - The University of Oslo and the Foundation for the Promotion of Norwegian Pharmacies (H. Nordeng-PI) (co-I).
Medication use in pregnance with focus on attitudes, perception of risk and mental well-being - The University of Oslo (H. Nordeng-PI) (co-I).
Long term neurodevelopmental outcome after exposure to psychotropic drugs during pregnance - The Norwegian Research Council (H. Nordeng-PI) (co-I).
International Registry for Gilenya in Multiple Sclerosis - Novartis Inc. (G. Koren-PI).
Developing GeneMed for Canada, Pilot Study - University of Toronto Centre for Applied Genomics (G. Koren-PI).
GeneMed in children - Ontario Ministry of Health (S. Ito-PI) (co-I).
CHIP-Child- Testing the Fetal Programming Hypothesis - CIHR (L. Magee-PI) (co-I).
Development of clinical practice guideline for pharmacogenetic testing - CIHR (B. Carleton-PI) (co-I).
Doctoral Research Award - Priority Announcement - Childhood Cancer (SHOPP), CIHR-Partnerships and Citizen Engineering/CIHR - Institute of Cancer Research/Paediatric Oncology Group of Ontario. (Lauren Hanly - PhD Candidate).
NIH - Pain in preterm infants in development and effects. (R. Grunan-PI) (Co-applicant).
The Ivey Chair in Molecular Toxicology, University of Western Ontario (PI).
CIHR - Canadian Pharmacogenetic Network for Drug Safety: (B Carleton, M Hayden, PIs) (co-investigator, site PI).
Walkerton Clean Water Center: Bisphenol A and children’s health(with Dr. Yanful). (co-PI)
CIHR - Renal handling of drugs during development (PI)
First Nation & Inuit Branch - Baseline biomonitoring studies and a survey of child-youth health as prerequisites to epidemiological studies to assess the health risk of the Attawapiskat first nation and Walpole island first nation. (J. Bend, PI) (Co-applicant).
North Carolina Translational and Clinical Science Institute. Hair cortisol as a biomarker of chronic HPA axis response to stress. (A. Sanders, PI) (Co-applicant)
American Association of Critical Nurses. The Vulnerable Infant Population (VIP) perinatal stress study. (Purdy I, UCLA, PI). (Co-applicant).
Pregnancy outcomes following gabapentin use: Results of a prospective comparative cohort study
Fujii H, Goel A, Bernard N, Pistelli A, Yates LM, Stephens S, Han JY, Matsui D, Etwell F, Einarson TR, Koren G, Einarson A
Neurology. 2013 Apr 3. [Epub ahead of print] PubMed PMID: 23553472
Pregnancy and isotretinoin therapy
Choi JS, Koren G, Nulman
ICMAJ. 2013 Apr 2; 185(6):508. doi: 10.1503/cmaj.113-2112. PubMed PMID: 23550057
A child exposed to primidone not prescribed for her
Tanoshima R, 't Jong GW, Merlocco A, Simpson J, Friedman JN, Colantonio D, Koren G
Ther Drug Monit. 2013 Apr; 35(2):145-9. doi: 10.1097/FTD.0b013e3182843206. PubMed PMID: 23503440.
Selected Pregnancy and Delivery Outcomes After Exposure to Antidepressant Medication: A Systematic Review and Meta-analysis
Ross LE, Grigoriadis S, Mamisashvili L, Vonderporten EH, Roerecke M, Rehm J, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung AJ
AMA Psychiatry. 2013 Apr 1; 70(4):436-43. doi: 10.1001/jamapsychiatry.2013.684. PubMed PMID: 23446732
Systematic Review of the Effects of Maternal Hypertension in Pregnancy and Antihypertensive Therapies on Child Neurocognitive Development
Reprod Toxicol. 2013 Mar 28. doi:pii: S0890-6238(13)00071-3. 10.1016/j.reprotox.2013.03.006 [Epub ahead of print] PubMed PMID: 23542230
Meconium Fatty Acid ethyl esters as biomarkers of late gestational ethanol exposure and indicator of ethanol-induced multi-organ injury in fetal sheep
Zelner I, Kenna K, Brien JF, Bocking A, Harding R, Walker D, Koren G
PLoS One. 2013;8(3):e59168. doi: 10.1371/journal.pone.0059168. Epub 2013 Mar 22. PubMed PMID: 23533604; PubMed Central PMCID: PMC3606447
Towards Identifying a Characteristic Neuropsychological Profile for Fetal Alcohol Spectrum Disorders. Specfic Caregiver-and Teacher-Rating
Stevens SA, Nash K, Fantus E, Nulman I, Rovet J, Koren G
J Popul Ther Clin Pharmacol. 2013;20(1):e53-62. Epub 2013 Mar 4. PubMed PMID: 23513046
Towards Identifying a Characteristic Neuropsychological Profile for Fetal Alcohol Spectrum Disorders. Analysis of the Motherisk FASD Clinic
Nash K, Stevens S, Rovet J, Fantus E, Nulman I, Sorbara D, Koren G
J Popul Ther Clin Pharmacol. 2013;20(1):e44-52. Epub 2013 Mar 4. PubMed PMID: 23513044
Water by the spoonful: Children of addiction
Can Fam Physician. 2013 Mar;59(3):e141-2. PubMed PMID: 23486813; PubMed Central PMCID: PMC3596221
Cancer chemotherapy and pregnancy
Koren G, Carey N, Gagnon R, Maxwell C, Nulman I, Senikas V
J Obstet Gynaecol Can. 2013 Mar;35(3):263-79. PubMed PMID: 23470115
Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy
Matok I, Clark S, Caritis S, Miodovnik M, Umans J, Hankins G, Koren G
J Clin Pharmacol. 2013 Mar; 53(3):334-8. doi: 10.1177/0091270012445207. Epub 2013 Jan 24. PubMed PMID: 23444286
A 2013 Updated Systematic Review & Meta-Analysis of 36 Randomized Controlled Trials; No Apparent Effects of Non Steroidal Anti-inflammatory Agents on the Risk of Bleeding After Tonsillectomy
Riggin L, Sommer D, Koren G, Ramakrishna J
Clin Otolaryngol. 2013 Feb 28. doi: 10.1111/coa.12106. [Epub ahead of print] PubMed PMID: 23448586
Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: A systematic review
Gijsen VM, Hesselink DA, Croes K, Koren G, de Wildt SN
Pediatr Transplant. 2013 Feb 28. doi: 10.1111/petr.12056. [Epub ahead of print] PubMed PMID: 23448292
Preemptive treatment of nausea and vomiting of pregnancy: results of a randomized controlled trial
Maltepe C, Koren G
Obstet Gynecol Int. 2013;2013:809787. doi: 10.1155/2013/809787. Epub 2013 Feb 17. PubMed PMID: 23476657; PubMed Central PMCID: PMC3588181
Safety of procedural sedation in pregnancy
Neuman G, Koren G
J Obstet Gynaecol Can. 2013 Feb; 35(2):168-73. PubMed PMID: 23470068
The maternal drinking history guide: development of a national educational tool
Koren G, Sarkar M, Rosenbaum C, Orrbine E
J Popul Ther Clin Pharmacol. 2013; 20(1):e42-3. Epub 2013 Feb 7. PubMed PMID: 23429281
Treating morning sickness PRN?
Can Fam Physician. 2013 Feb; 59(2):150-1. PubMed PMID: 23418239
Neonatal outcomes after gestational exposure to nitrofurantoin
Nordeng H, Lupattelli A, Romøren M, Koren G
Obstet Gynecol. 2013 Feb; 121(2 Pt 1):306-13. doi: http://10.1097/AOG.0b013e31827c5f88. PubMed PMID: 23344280
Higher cortisol predicts less improvement in verbal memory performance after cardiac rehabilitation in patients with coronary artery disease
Saleem M, Herrmann N, Swardfager W, Oh PI, Shammi P, Koren G, Van Uum S, Kiss A, Lanctôt KL
Cardiovasc Psychiatry Neurol. 2013;2013:340342. doi: 10.1155/2013/340342. Epub 2013 Jan 16. PubMed PMID: 23401745; PubMed Central PMCID: PMC3562642
Mothersisk update: reproductive outcomes after assisted conception
Neuman G, Koren G
Can Fam Physician. 2013 Jan; 59(1):33-4, 36. PubMed PMID: 23341654
Ethical issues in pharmacologic research in women undergoing pregnancy termination: a systematic review and survey of researchers
Gedeon C, Nava-Ocampo AA, Koren G
Obstet Gynecol Int. 2012; 2012:724591
The safety of fetal exposure to proton-pump inhibitors during pregnancy
Matok I, Levy A, Wiznitzer A, Uziel E, Koren G, Gorodischer R
Dig Dis Sci. 2012;699-705
Hair cortisol as a biological marker of chronic stress: Current status, future directions, and unanswered questions
Russell E, Koren G, Rieder M, Van Uum S
Central nervous system depression of neonates breastfed by mothers receiving oxycodone for postpartum analgesia
Lam J, Kelly L, Ciszkowski C, Landsmeer ML, Nauta M, Carleton BC, Hayden MR, Madadi P, Koren G
J Pediatr. 2012; 33-7
Hair as a biomarker of polybrominated ditheyl ethers' exposure in infants, children and adults
Aleksa K, Liesivuouri J, Koren G
Toxicol Lett. 2011. [Epub ahead of print]
Simultaneous detection of seventeen drugs of abuse and metabolites in hair using solid phase micro extraction (SPME) with GC/MS
Aleksa K, Walasek P, Fulga N, Kapur B, Gareri J, Koren G
Forensic Sci Int. 2011. [Epub ahead of print]
The effect of distant reiki on pain in women after elective Caesarean section: a double-blinded randomised controlled trial
Vandervaart S, Berger H, Tam C, Goh YI, Gijsen VM, de Wildt SN, Taddio A, Koren G
BMJ. 2011; e000021
Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite
Gunness P, Aleksa K, Bend J, Koren G
Transl Res. 2011; 290-301
Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients
Gijsen V, Mital S, van Schaik RH, Soldin OP, Soldin SJ, van der Heiden I, Nulman I, Koren G, de Wildt SN
J Heart Lung Transplant. 2011; 1352-9
Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic
Nurmohamed L, Moretti ME, Schechter T, Einarson A, Johnson D, Lavigne SV, Erebara A, Koren G, Finkelstein Y
Am J Obstet Gynecol. 2011; 533.e1-3
The transfer of 6-mercaptopurine in the dually perfused human placenta
Hutson JR, Lubetsky A, Walfisch A, Ballios BG, Garcia-Bournissen F, Koren G
Reprod Toxicol. 2011; 349-53
Phone: 519-661-2111 x 83128
Email: gkoren [at] uwo [dot] ca
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