Rodney P. DeKoter
Affiliations
Associate Scientist, Division of Genetics & Development, Children’s Health Research Institute
Associate Professor, Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry,
Western University
Affiliate Member, Division of Experimental Oncology, Western University
How my research helps children
The goal of our research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and acute myeloid leukemia (AML). These diseases are rare but devastating since there are few treatment options. We are working hard to develop new cutting-edge therapies to fight these diseases.
Research
Research Team
My research team includes Marek Gruca and Stepen Li (graduate students) and Sherry Xu (research technician). Our laboratory takes on summer students and undergraduate students on a regular basis.
Future Research Plans
We look forward to establishing collaborations with rheumatologists and hematologists to investigate the genetic causes of autoimmune diseases and myeloid leukemia.
Awards & Grants
Awards & Grants
Funding in support of “Graded regulation of gene expression by PU.1” – Awarded by National Sciences and Engineering Research Council
Funding in support of “Functions of related Ets transcription factors in B cells” – Canadian Institutes of Health Research
Funding in support of “Role of PU.1 in generation of myeloid suppressor cells after thermal injury” – Shriners Hospitals of America
Funding in support of “A mouse model of myeloid leukemia” – Awarded by Ohio Cancer Research Associates, USA
Recent Publications
Publications
PU.1 positively regulates GATA-1 expression in mast cells Takemoto, C.M., Brandal, S., Jegga, A. G., Lee, Y.-N., Shahlaee, A., Ying, Y., DeKoter, R.P., and McDevitt, M.A. J Immunol. 2010 Apr 15;184(8):4349-61
Regulation of lymphoid versus myeloid fate choice by Mef2c Stehling-Sun, S., Nutt, S. L., Dade, J., DeKoter, R. P., and Camargo, F. D. Nat Immunol. 2009 Mar;10(3):289-96
Ectopic Expression of Spi-C impairs B cell development and function Zhu, X., Schweitzer, B. L., Romer, E. J., Sulentic, C. E. W., and DeKoter, R. P. European Journal of Immunology 2008 38:2587-2599
Myeloid gene activation and T cell/natural killer cell gene repression in cells expressing two distinct PU.1 concentrations Kamath, M. B., Houston, I. B., Janovski, A. J., Zhu, X., Gowrisankar, S., Jegga, A. G., and DeKoter, R. P. Leukemia 2008 22:1214-1225
Analysis of concentration-dependent functions of PU.1 in hematopoiesis using mouse models. DeKoter R.P., Kamath MB, Houston IB Blood Cells Mol Dis. 2007 Nov-Dec;39(3):316-20.
Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality Houston IB, Kamath MB, Schweitzer BL, Chlon TM, DeKoter R.P. Exp Hematol. 2007 Jul;35(7):1056-68.
Regulation of the Interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells DeKoter R.P., Schweitzer BL, Kamath MB, Jones D, Tagoh H, Bonifer C, Hildeman DA, Huang KJ. J Biol Chem. 2007 May 11;282(19):14194-204
PU.1 immortalizes hematopoietic progenitors in a GM-CSF-dependent manner. Houston IB, Huang KJ, Jennings SR, DeKoter R.P.. Exp Hematol. 2007 Mar;35(3):374-384
Spi-C has opposing effects to PU.1 on gene expression in pro-B cells Schweitzer BL, Huang KJ, Kamath MB, Emelyanov AV, Birshtein BK, DeKoter R.P. J Immunol. 2006 Aug 15;177(4):2195-207
Contact
Phone: 519-661-2084
Fax: 519-661-3499
Email: rdekoter [at] schulich [dot] uwo [dot] ca
Web: http://publish.uwo.ca/~rdekoter
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