Bryan Richardson

Maternal, Fetal & Newborn Health Dr. Bryan Richardson
Scientist
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Affiliations

Scientist, Division of Maternal, Fetal & Newborn Health, Children’s Health Research Institute
Professor, Departments of Obstetrics & Gynaecology, Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University

How my research helps children

My research interests are in the area of fetal and neonatal development in relation to varying conditions during pregnancy, with a focus on that of the brain.  With a better understanding of normal developmental processes and pregnancy conditions leading to abnormal development as well as the means by which this occurs, we should better enable preventative and/or treatment strategies.

Research

Current Research Activities

Current research activities are in the following three areas:

  1. Study of the impact of pregnancy conditions, labour, and labour related events on fetal/neonatal inflammatory processes at the time of birth.  We have been studying normal low risk pregnancies as well as those with adverse pregnancy conditions including fetal growth restriction, pregnancy induced hypertension, and post dates pregnancies, and the impact on proinflammatory/anti-inflammatory cytokines and chemokines measured in the umbilical cord blood at the time of delivery.
  2. Study of the utility of monitoring fetal brain electrical activity and heart rate variability as measures of well-being during labour in high risk pregnancies to better delineate need for expedited delivery.  This study has initially been in chronically catheterized fetal sheep near term to determine the feasibility of acquiring satisfactory brain electrical measurements from the fetal scalp as well as their changes in relationship to varying hypoxic-acidemic insult and thereby the clinical utility for identifying such.
  3. Study to determine the impact of chronic hypoxemia with fetal growth restriction in pregnant guinea pigs on measures of brain development with a focus on neuronal connectivity and white matter development.  Using pregnant guinea pigs near term studies have been undertaken to determine the effect of induced fetal growth restriction on markers of neuronal connectivity and white matter myelinization using immunohistochemistry.

Research Team

The Perinatal Research Lab is located on the fifth floor of the Dental Science Building of Western University.  Our Immunohistochemistry Core is located on the fifth floor of the Victoria Research Labs adjacent to London Health Sciences Centre – Victoria Hospital on Commissioners Road.  The Research Team presently includes two graduate students, Ms. Karolina Piorkowska and Mr. Alex Xu; a research associate, Mr. Brad Matushewski who provides support for all animal surgeries and experimentation; and immunohistochemistry technical support with Ms. Karen Nygard.

Future Research Plans

I am collaborating with Drs. Rob Hammond and Tim Regnault from the Departments of Pathology and Ob/Gyn, respectively, to determine the impact of adverse pregnancy conditions and labour related events on fetal/neonatal inflammation at the time of birth.  I am collaborating with Dr. Martin Frasch from the Department of Obstetrics and Gynaecology University of Montreal and Dr. Michael Ross from the Department of Obstetrics and Gynecology University of California Los Angeles on the utility of fetal brain electrical activity and heart rate variability to better delineate fetal wellbeing with induced hypoxic-acidemia as might be seen during human labour.  Lastly, I am collaborating with Dr. Rob Hammond from the Department of Pathology to determine the impact of fetal growth restriction on brain development using immunohistochemistry measures of neuronal connectivity and myelinization.

Awards & Grants

Awards & Grants

Funding in support of "Maternal undernourishment and the impact on fetal and placental development" – Awarded by Children's Health Research Institute (CHRI)

Funding in support of "NeuroDevelopmental Network" – Awarded by Networks of Centres of Excellence (NCE)

Funding in support of "The effect of labour events on umbilical cord inflammatory cytokines" – Awarded by Children's Health Research Institute (CHRI)

Funding in support of "IRF studentship application" – Awarded by Lawson Health Research Institute (LHRI)

Funding in support of "Fetal EEG/FHR monitoring for predicting fetal health during labour" – Awarded by Women's Development Council Grant

Canada Research Chair, Tier 1 in Fetal/Neonatal Health and Development

Royal College Visiting Professorship Research Award – Awarded by Royal College of Physicians & Surgeons

National Specialty Society Annual Meeting Grant, Royal College of Physicians and Surgeons of Canada Speaker, SOGC, June 2010

Funding in support of “Fetal brain development: Impact of acute and chronic hypoxia” – Awarded by Canadian Institutes of Health Research (CIHR)   

Funding in support of “Fetal/neonatal health and development” – Awarded by Canada Research Chairs (CRC)   

Funding in support of “Fetal growth restriction: Mechanisms and outcomes” – Awarded by Canadian Institutes of Health Research (CIHR)   

Funding in support of “Intrapartum fetal EEF monitoring” – Awarded by University of Western Ontario

Funding in support of “Acute animal testing of prototype fetal heart rate (FHR)/electroencephalogram (EEG) for early detection and prediction of fetal academia and associated health compromise during labour” – Awarded by Ministry of Research and Innovation (MRI)   

Funding in support of “Inflammation and cholinergic anti-inflammatory pathway in pre- and near-term fetal sheep” – Awarded by Lawson Health Research Institute   

Funding in support of “Fetal growth restriction: mechanisms and outcomes” – Awarded by University of Western Ontario   

Funding in support of “NeuroDevNet” – Awarded by Network Centres of Excellence (NCE)   

Funding in support of “The effect of labour events on umbilical cord inflammatory cytokines” – Awarded by Children’s Health Research Institute   

Funding in support of “IRF studentship application” – Awarded by Lawson Health Research Institute




Recent Publications

Publications

Cytokines in umbilical cord blood and the impact of labor events in low-risk term pregnancies
Chan CJ, Summers KL, Chan NG, Hardy DB, Richardson BS
Early Human Development. 2013 Sept 14; 89:1005-1010

Correlation of arterial fetal base deficit and lactate changes with severity of variable heart rate decelerations
Ross MG, Jessie M, Amaya K, Matushewski B, Frasch MG, Richardson BS
Am J Obstet Gynecol. 2013 Apr 1; 208 (4):285.e1-6

The impact of intermittent umbilical cord occlusions on the inflammatory response in pre-term fetal sheep
Prout AP, Frasch MG, Veldhuizen R, Hammond R, Matushewski B, Richardson BS
PLoS ONE. 2012; 7(6):e39043. doi:10.1371/journal.pone.0039043

Neonatal outcomes are associated with latency after preterm premature rupture of membranes
Nayot D, Penava D, daSilva O, Richardson BS, de Vrijer B
J Perinatol 2012 Mar 15 [Epub ahead of print]

Central stiffening in adulthood linked to aberrant aortic remodeling under suboptimal intrauterine conditions
Thompson JA, Gros R, Richardson BS, Piorkowska, Regnault TRH
Am J Physiol Regul Integr Comp Physiol. 2011 Sept 7

Monitoring fetal electrocortical activity during labour for predicting worsening acidemia: a prospective study in the ovine fetus near term
Frasch MG, Keen AE, Gagnon R, Ross MG, Richardson BS
PLoS ONE. 2011; 6(7):e22100

Maturational changes and effects of chronic hypoxemia on electrocortical activity in the ovine fetus
Keen AE, Frasch MG, Sheehan MA, Matushewski BJ, Richardson BS
Brain Res. 2011; 1402:38-45

Electrocortical activity in the near-term ovine fetus: automated analysis using amplitude and frequency components
Keen AE, Frasch MG, Sheehan MA, Matushewski BJ, Richardson BS
Brain Res. 2011; 1402:30-37

The effect of intermittent umbilical cord occlusion on elastin composition in the ovine fetus
Thompson JA, Folliot SA, Richardson BS, Gagnon R, Regnault TRH
Reprod Sci. 2011; 18(10):990-997

Chronic intrauterine hypoxia interferes with aortic development in the late gestation ovine fetus
Thompson JA, Richardson BS, Gagnon R, Regnault TRH
J Physiology. 2011 May 3

IL-6 and TNFα across the umbilical circulation in term pregnancies: Relationship with labour events
Duncombe G, Veldhuizen RAW, Gratton R, Han V, Richardson BS
Early Hum Dev. 2010 Feb;86(2):113-7

Cerebral protein synthesis in the ovine fetus near term with amino acid infusion and insulin induced hypo amino acidemia
MacLachlan JN, McCallum JD, Smith N, Matushewski B, Richardson B
Neonatology. 2010 May 4;98(4):297-304

Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus
Prout AP, Frasch MG, Veldhuizen RAW, Hammond R, Ross MG, Richardson BS
Am J Obstet Gynecol. 2010 Jan;202(1):82.e1-9

Behavioural state linkage in the ovine fetus near term
Rao N, Keen A, Czikk M, Frasch M, Richardson BS
Brain Res. 2009 Jan 23;1250:149-56

Measures of acidosis with repetitive umbilical cord occlusions leading to fetal asphyxia in the ovine fetus near term
Frasch MG, Mansano RZ, Gagnon R, Richardson BS, Ross MG
Am J Obstet Gynecol. 2009 Feb;200(2):200

BDNF and TrkB in the preterm and near-term ovine fetal brain and the effect of intermittent umbilical cord occlusion
Nishigori H, Mazzuca DM, Nygard KL, Han VK, Richardson BS
Reprod Sci. 2008 Nov;15(9):895-905

Feto-maternal safety of intracervical sodium nitroprusside application in sheep
Blasi I, Richardson B, Volpe A, Facchinetti F
Reprod Sci 15:690-695, 2008

Effects of antenatal glucocorticoids on cerebral protein synthesis in the preterm ovine fetus
McCallum J, Smith N, MacLachlan J, Coksaygan T, Schwab M, Nathanielsz P, Richardson B
Am J Obstet Gynecol. 2008 Jan;198(1):103.e1-6

Placental 11β-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery
Dy J, Guan H, Sampath-Kumar R, Richardson BS, Yang K
Placenta. 2008 Feb;29(2):193-200
   
Induced hyper and hypo amino acidemia in the ovine fetus near term:  effects on electrocortical activity
MacLachlan JN, Hemstreet S, Matushewski B, McCallum JD, Richardson B
Reprod Sci. 2008 Sep;15(7):710-9

Additional publications

Contact

Contact

Phone: (519) 646-6100, x66380
Fax: (519) 646-6213
Email: brichar1 [at] uwo [dot] ca